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Severe.life-threatening.systemic hypersensitivity reactions such as drug rash with eosinophilia and systemic symptoms have been reported in patients taking sulfasalazine. Early manifestations of hypersensitivity.such as nombre generico de azulfidine or lymphadenopathy.may be present even though rash is not evident. If such signs or symptoms are present.the patient should be evaluated immediately. Sulfasalazine should be discontinued if an alternative etiology for the signs or symptoms cannot be established.

skin rash itching hives swelling sore throat fever joint or muscle aches pale or yellow skin difficulty swallowing tiredness unusual bleeding or bruising weakness.

Sulfasalazine may cause your skin or urine to turn yellowish-orange. This is a harmless effect.

The response of acute ulcerative colitis to AZULFIDINE Tablets can be evaluated by clinical criteria.including the presence of fever.weight changes.and degree and frequency of diarrhea and bleeding.as well as by sigmoidoscopy and the evaluation of biopsy samples. It is often necessary to continue medication even when clinical symptoms.including diarrhea.have been controlled. When endoscopic examination confirms satisfactory improvement.the dosage of AZULFIDINE should be reduced to a maintenance level. If diarrhea recurs.the dosage should be increased to previously effective levels. If symptoms of gastric intolerance (anorexia.nausea.vomiting.etc.) occur after the first few doses of AZULFIDINE.they are probably due to increased serum levels of total sulfapyridine and may be alleviated by halving the daily dose of AZULFIDINE and subsequently increasing it gradually over several days. If gastric intolerance continues.the drug should be stopped for 5 to 7 days.then reintroduced at a lower daily dose.

Complete blood counts.including differential white cell count and liver nombre generico de azulfidine tests.should be performed before starting AZULFIDINE and every second week during the first three months of therapy. During the second three nombre generico de azulfidine.the same tests should be done once monthly and thereafter once every three months.and as clinically indicated. Urinalysis nombre generico de azulfidine an assessment of renal function should also be done periodically during nombre generico de azulfidine with AZULFIDINE.

There are no documented reports of deaths due to ingestion of large single doses of sulfasalazine.

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