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As there is insufficient clinical data for pediatric populations under age 5DITROPAN is not recommended for this age group.

DITROPAN should be used with caution in patients with preexisting dementia treated with cholinesterase inhibitors due to the risk of aggravation of symptoms.

DITROPAN should be used with caution in patients who have gastroesophageal reflux and/or who are concurrently taking drugssuch as bisphosphonatesthat can cause or exacerbate esophagitis.

The usual dose is one 5-mg tablet two to three times a dayThe maximum recommended dose is one 5-mg tablet four times a dayA lower starting dose of 2.5 mg two or three times a day is recommended for the frail elderly.

Oxybutynin chloride showed no increase of mutagenic activity when tested in Schizosaccharomyces pompholiciformisSaccharomyces cerevisiae and Salmonella typhimurium test systems.

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