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It is important to be aware that selegiline may have pharmacological effects unrelated to MAO-B inhibitionAs noted abovethere is some evidence that it may increase dopaminergic activity by other mechanismsincluding interfering with dopamine re-uptake at the synapseEffects resulting from selegiline administration may also be mediated through its metabolitesTwo of its three principal metabolitesamphetamine and methamphetaminehave pharmacological actions of their ownthey interfere with neuronal uptake and enhance release of several neurotransmitterse.gnorepinephrinedopamineserotoninHoweverthe extent to which these metabolites contribute to the effects of selegiline are unknown.
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