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Theophylline has been studied in Ames salmonellain vivo and in vitro cytogeneticsmicronucleus and Chinese hamster ovary test systems and has not been shown to be genotoxic.

Miscellaneous Other factors associated with decreased theophylline clearance include the third trimester of pregnancysepsis with multiple organ failureand hypothyroidismCareful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients with any of these conditionssee WARNINGSOther factors associated with increased theophylline clearance include hyperthyroidism and cystic fibrosis.

The Quibron-T/SR brand name has been discontinued in the U.SIf generic versions of this product have been approved by the FDAthere may be generic equivalents available.

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